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Antimicrobial Resistance (AMR) is an occurrence in which bacteria, viruses, fungi, and parasites evolve over time and cease to respond to antibiotics, making infections more difficult to cure and raising the risk of disease transmission, life-threatening sickness, and death. It is predicted that AMR related deaths will reach 10 million per year by 2050, which would even overtake cancer as the leading cause of death worldwide.
AMR is a problem with various aspects to be taken into consideration, the solution for which is multifaceted. One of the strategies that can be employed is that we must alter how they target pathogens, if we want antibiotics to continue to work. We could also come up with solutions using Artificial Intelligence (AI) and quantum computing. Overall, multi-sectoral collaboration is needed to stop AMR from becoming the next big global health threat.
Kindly share your thoughts on strategies against Antimicrobial Resistance.
Sources:
//www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
//www.weforum.org/agenda/2022/11/antimicrobial-resistance-week-the-silent-pandemic-solutions
Posted : November 28, 2022 5:00 pm
Various genetic and phenotypic AMR mechanisms allow bacterial pathogens to withstand antibiotic exposure. A permanent change in antimicrobial susceptibility is linked to genetic factors, such as the acquisition of mobile genetic elements and mutations in chromosomal genes causing antibiotic resistance. Temporary reductions in antibiotic sensitivity such as tolerance are frequently correlated with phenotypic processes.
//www.sciencedirect.com/science/article/pii/S1359644622001258
Posted : December 26, 2022 3:55 pm
To combat the rise in AMR rates, it is critical to implement an institutional antibiotic stewardship program that monitors correct antibiotic use, controls antibiotics, and generates antibiograms. Furthermore, these types of tools may aid in the treatment of patients in the event of a medical emergency in which a physician is unable to wait for bacterial culture results.
Currently, two methods are widely used to diagnose AMR i.e. antimicrobial susceptibility testing (AST), and whole-genome sequencing for antimicrobial susceptibility testing (WGS-AST). WGS-AST provides rapid, consistent, and accurate diagnosis for AMR but it involves studying large data sets and thus is very time-consuming. To make it fast, many researchers have come out combining the orthodox AST methodology with supervised machine learning to increase the accuracy and reduce the timing to less than 3 h. An IR-spectrometer method has been produced that combines infrared (IR) spectroscopy with an artificial neural network which can deliver result in 30 min.
Posted : April 10, 2023 10:40 pm
Antimicrobial resistance (AMR) is the ability of microorganisms to persist or grow in the presence of drugs designed to inhibit or kill them. These drugs, called antimicrobials, are used to treat infectious diseases caused by microorganisms such as bacteria, fungi, viruses and protozoan parasites.
When microorganisms become resistant to antimicrobials, standard treatments are often ineffective, and in some cases, no drugs provide effective therapy. Consequently, treatments fail. This increases illness and mortality in humans, animals and plants. For agriculture, this causes production losses, damages livelihoods and jeopardizes food security. Moreover, AMR can spread among different hosts and the environment, and antimicrobial resistant microorganisms can contaminate the food chain
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Posted : April 14, 2023 3:52 pm
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